Nature Communications (Jun 2021)
Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface
- Eric M. Trautmann,
- Daniel J. O’Shea,
- Xulu Sun,
- James H. Marshel,
- Ailey Crow,
- Brian Hsueh,
- Sam Vesuna,
- Lucas Cofer,
- Gergő Bohner,
- Will Allen,
- Isaac Kauvar,
- Sean Quirin,
- Matthew MacDougall,
- Yuzhi Chen,
- Matthew P. Whitmire,
- Charu Ramakrishnan,
- Maneesh Sahani,
- Eyal Seidemann,
- Stephen I. Ryu,
- Karl Deisseroth,
- Krishna V. Shenoy
Affiliations
- Eric M. Trautmann
- Neurosciences Graduate Program, Stanford University
- Daniel J. O’Shea
- Neurosciences Graduate Program, Stanford University
- Xulu Sun
- Department of Biology, Stanford University
- James H. Marshel
- Department of Bioengineering, Stanford University
- Ailey Crow
- Department of Bioengineering, Stanford University
- Brian Hsueh
- Neurosciences Graduate Program, Stanford University
- Sam Vesuna
- Department of Bioengineering, Stanford University
- Lucas Cofer
- Department of Electrical Engineering, Stanford University
- Gergő Bohner
- Gatsby Computational Neuroscience Unit, University College London
- Will Allen
- Neurosciences Graduate Program, Stanford University
- Isaac Kauvar
- Neurosciences Graduate Program, Stanford University
- Sean Quirin
- Department of Bioengineering, Stanford University
- Matthew MacDougall
- Department of Neurosurgery, Stanford University
- Yuzhi Chen
- Center for Perceptual Systems, University of Texas
- Matthew P. Whitmire
- Center for Perceptual Systems, University of Texas
- Charu Ramakrishnan
- Department of Bioengineering, Stanford University
- Maneesh Sahani
- Gatsby Computational Neuroscience Unit, University College London
- Eyal Seidemann
- Center for Perceptual Systems, University of Texas
- Stephen I. Ryu
- Department of Electrical Engineering, Stanford University
- Karl Deisseroth
- Neurosciences Graduate Program, Stanford University
- Krishna V. Shenoy
- Neurosciences Graduate Program, Stanford University
- DOI
- https://doi.org/10.1038/s41467-021-23884-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Surface two-photon imaging of the brain cannot access somatic calcium signals of neurons from deep layers of the macaque cortex. Here, the authors present an implant and imaging system for chronic motion-stabilized two-photon imaging of dendritic calcium signals to drive an optical brain-computer interface in macaques.
