Association of paraspinal muscle morphology or composition with sagittal spinopelvic alignment: a systematic review and meta-analysis

Abstract

Abstract Purpose The aim of this study was to evaluate the association of paraspinal muscle morphology and composition with sagittal spinopelvic alignment (SSA). Methods This review was registered at PROSPERO (CRD42022371879). Four databases including PubMed, Embase, Cochrane, and Web of Science were searched from their inception until December 15, 2024. The scope of paraspinal muscles included multifidus (MF), erector spinae (ES), psoas major (PM), and paraspinal extensor muscles (PEM; combined multifidus and erector spinae). The cross-sectional area (CSA) and fat signal fraction (FSF) were the metrics for quantifying paraspinal muscle morphology and composition, respectively. The outcomes of interest were SSA parameters, including C7-S1 sagittal vertical axis (SVA), thoracic kyphosis (TK), lumbar lordosis (LL), pelvic tilt (PT), sacral slope (SS), pelvic incidence (PI), and PI minus LL mismatch (PI − LL). The methodological quality and risk of bias of each included studies was assessed using the Newcastle-Ottawa Scale and its adapted form. Correlation coefficients extracted from included studies were transformed to a Fisher’s z correlational coefficient to perform a meta-analysis and to generate a pooled effect size (z) and 95% confidence intervals (CIs). Results Sixteen observational studies with 1535 participants were included in the meta-analysis. We found a positive association of paraspinal muscle CSA with TK (MFCSA, z = 0.17, 95% CI: 0.01 to 0.32, p = 0.041; PEMCSA, z = 0.17, 95% CI: 0.06 to 0.28, p = 0.002) and LL (PMCSA, z = 0.12, 95% CI: 0.02 to 0.22, p = 0.019), whereas a negative correlation with SVA (MFCSA, z = − 0.35, 95% CI: −0.67 to − 0.02, p = 0.036; PEMCSA, z = − 0.25, 95% CI: −0.45 to − 0.05, p = 0.015), PT (PMCSA, z = − 0.22, 95% CI: −0.39 to − 0.05, p = 0.012), PI (PMCSA, z = − 0.13, 95% CI: −0.23 to − 0.02, p = 0.020), and PI-LL (MFCSA, z = − 0.50, 95% CI: −0.69 to − 0.30, p < 0.00001; PMCSA, z = − 0.20, 95% CI: −0.34 to − 0.05, p = 0.007; PEMCSA, z = − 0.28, 95% CI: −0.38 to − 0.18, p < 0.00001). Meanwhile, paraspinal muscle FSF showed a positive correlation with SVA (PEMFSF, z = 0.39, 95% CI: 0.30 to 0.47, p < 0.00001), PT (PEMFSF, z = 0.45, 95% CI: 0.35 to 0.54, p < 0.00001), and PI-LL (PEMFSF, z = 0.29, 95% CI: 0.17 to 0.41, p < 0.00001), while a negative correlation with PI (PMFSF, z = − 0.14, 95% CI: −0.27 to − 0.01, p = 0.029) and SS (PEMFSF, z = − 0.25, 95% CI: −0.41 to − 0.08, p = 0.004). We also observed the associations were stronger in populations without degenerative spinal diseases, in studies that used computed tomography for paraspinal muscle morphology and composition assessment, and in studies with moderate study quality. Of the 15 significant associations reported here, only 3 were supported by moderate to high-level evidence, while others were supported by very low to low evidence certainty. Conclusion Paraspinal muscle morphology and composition were associated with SSA. Further studies are warranted to establish causality and to elucidate the underlying mechanisms.

Keywords

• Paraspinal muscles
• Sarcopenia
• Fat infiltration
• Sagittal spinopelvic alignment
• Meta-analysis