Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by Spray-Cooling
Carmen S. Favaro-Trindade,
Fernando E. de Matos Junior,
Paula K. Okuro,
João Dias-Ferreira,
Amanda Cano,
Patricia Severino,
Aleksandra Zielińska,
Eliana B. Souto
Affiliations
Carmen S. Favaro-Trindade
Faculty of Animal Sciences and Food Engineering (FZEA), University of São Paulo, Rua Duque de Caxias, 225, Jardim Elite, Pirassununga 13625-900, Brazil
Fernando E. de Matos Junior
Faculty of Animal Sciences and Food Engineering (FZEA), University of São Paulo, Rua Duque de Caxias, 225, Jardim Elite, Pirassununga 13625-900, Brazil
Paula K. Okuro
Faculty of Animal Sciences and Food Engineering (FZEA), University of São Paulo, Rua Duque de Caxias, 225, Jardim Elite, Pirassununga 13625-900, Brazil
João Dias-Ferreira
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
Amanda Cano
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Patricia Severino
Industrial Biotechnology Program, University of Tiradentes (UNIT), Av. Murilo Dantas 300, Aracaju 49032-490, Brazil
Aleksandra Zielińska
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
Eliana B. Souto
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.
