FEATURES OF FREE RADICAL OXIDATION AND METABOLIC ACTIVITY OF VASCULAR ENDOTHELIUM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

Objective: To study the features of free radical oxidation and metabolic activity of the vascular endothelium in patients with chronic obstructive pulmonary disease (COPD). Methods: The results of the examination of 58 patients with COPD aged 28-54 years who were treated at the City Medical Center № 2 named after Academician K.T. Tadzhiev of Dushanbe city. There were 32 men (52.2%), and 26 women (44.8%). Free radical oxidation and the antioxidant system were predetermined by the content of reactive oxygen species (ROS), the amount of malondialdehyde (MDA), and the activity of superoxide dismutase (SOD). The state of the vascular endothelium was assessed by the content of C-reactive protein (CRP), fibrinogen, von Willebrand factor, total cholesterol, LDLP, and HDLP. Results: In patients with COPD in the serum, the intensification of free radical oxidation was noted in the form of an increase in the content of ROS by 30.1%, MDA by 125% and a decrease in SOD activity by 43.2% compared to the control. As a result, there is an imbalance between oxidants and antioxidants with the development of oxidative stress, which plays an important role in the pathogenesis of COPD. A study of the state of the vascular endothelium in patients with COPD revealed an increase in CRP by 16 times, fibrinogen by 61.5%, von Willebrand factor by 33.7%, total cholesterol by 30%, LDLP by 61.5% against a decrease in HDLP by 43.4% compared with control data. A correlation of ROS with fibrinogen (r=0.733817) was noted, which ultimately leads to endothelial dysfunction and the development of thromboembolic complications Conclusion: The course of COPD is accompanied by the development of a systemic inflammatory response, the starter of the mechanism which is oxidative stress, accompanied by an intensification of free radical oxidation, depletion of the antioxidant system. Oxidative stress contributes to damage to the vascular endothelium, the criteria of which are increased levels of CRP, fibrinogen, von Willebrand factor and an atherogenic lipid spectrum disorder (increased LDLP and total cholesterol, along with a decrease in HDLP)

Keywords

• copd
• free radical oxidation
• endothelium
• endothelial dysfunction
• biochemical studies.