Nature Communications (Jan 2020)

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

  • John C. Charpentier,
  • Di Chen,
  • Philip E. Lapinski,
  • Jackson Turner,
  • Irina Grigorova,
  • Joel A. Swanson,
  • Philip D. King

DOI
https://doi.org/10.1038/s41467-019-13997-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Macropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to an endolysosomal compartment to sustain mTORC1 activation.