Journal of Experimental & Clinical Cancer Research (Oct 2009)

Polymorphisms of the <it>ICAM-1 </it>exon 6 (E469K) are associated with differentiation of colorectal cancer

  • Wen Jin-Kun,
  • Han Yi,
  • Liu Yue-Ping,
  • Miao Sui-Bing,
  • Liu Ya-bin,
  • Liu Bin,
  • Li Bing-hui,
  • Wang Qing-lei,
  • Han Mei

DOI
https://doi.org/10.1186/1756-9966-28-139
Journal volume & issue
Vol. 28, no. 1
p. 139

Abstract

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Abstract Background Genetic factors are thought to play a role in development for colorectal carcinogenesis. ICAM-1 is a polymorphic gene, thus, the present study investigated the relationship between the polymorphisms of ICAM-1 and the susceptibility and phenotypical characteristics of colorectal cancer (CRC). Methods The polymorphisms at ICAM-1 exon 4 (G241R) and exon 6 (E469K) were detected by PCR with sequence-specific primers. The relationship between specific genotypes of ICAM-1 and differentiation of CRC was evaluated by the histological grade. Results We showed only GG genotype of ICAM-1 individuals in either CRC or normal controls. The KK genotype of ICAM-1 K469E was found more frequently than in the controls (P P Conclusion The findings indicate that polymorphisms of G241R are rare in Chinese population and that KK genotype of ICAM-1 K469E is significantly associated with well differentiation of CRC.