Российский паразитологический журнал (Oct 2019)
Optimal dosage of a new fenasal dosage form based on supramolecular nanoscale delivery systems in horses with anoplocephalidose
Abstract
Aim of the study is to.evaluate optimal dosages and develop a technology for the use of a new niclosamide pharmaceutical form based on supramolecular nanoscale delivery systems. Materials and methods. The experiment was performed on 50 Kazakh horses spontaneously invaded by cestodes. The animals were divided according to the principle of analogs into treatment and control groups of 10 heads each. The animals in Groups 1, 2, and 3 were orally administered with a complex of niclosamide with arabinogalactan in the ratio 1:2 (investigational drug) at dosages of 10 mg/kg, 20 mg/kg and 30 mg/kg in terms of active substance (AS), respectively. Animals in Group 4 received a base niclosamide formulation (fenasal) in the recommended therapeutic dose of 100 mg/kg. Animals in control group did not receive any antihelmintic. The drug efficacy was estimated based on copro-ovoscopic studies prior to and 18 days after deworming. Results and discussion. The experiment has shown 100% efficacy of the investigational drug in a ratio of 1: 2 at dosages of 20 and 30 mg/kg by AS in horses with anoplocephalidose. The efficacies of investigational drug in a ratio of 1:2 at a dosage of 10 mg/kg by AS and fenasal at a dosage of 100 mg/ kg were the same.
