CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

Jiao Fan; Lifeng Liu; Qingyan Liu; Yu Cui; Binwei Yao; Minghua Zhang; Yabing Gao; Yesheng Fu; Hongmiao Dai; Jingkun Pan; Ya Qiu; Cui Hua Liu; Fuchu He; Yu Wang; Lingqiang Zhang

doi:10.1038/s41467-018-07895-3

Nature Communications (Jan 2019)

CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

Jiao Fan,
Lifeng Liu,
Qingyan Liu,
Yu Cui,
Binwei Yao,
Minghua Zhang,
Yabing Gao,
Yesheng Fu,
Hongmiao Dai,
Jingkun Pan,
Ya Qiu,
Cui Hua Liu,
Fuchu He,
Yu Wang,
Lingqiang Zhang

Affiliations

Jiao Fan: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Lifeng Liu: Department of Cardiology, Chinese PLA General Hospital
Qingyan Liu: Center of Therapeutic Research for Liver Cancer, 302 Military Hospital of China
Yu Cui: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Binwei Yao: Department of Experimental Pathology, Beijing Institute of Radiation Medicine
Minghua Zhang: Clinical Pharmacy Laboratory, Chinese PLA General Hospital
Yabing Gao: Department of Experimental Pathology, Beijing Institute of Radiation Medicine
Yesheng Fu: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Hongmiao Dai: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Jingkun Pan: Institute of Geriatrics, National Clinical Research Center of Geriatrics Disease, Chinese PLA General Hospital
Ya Qiu: Institute of Geriatrics, National Clinical Research Center of Geriatrics Disease, Chinese PLA General Hospital
Cui Hua Liu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Fuchu He: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Yu Wang: Department of Cardiology, Chinese PLA General Hospital
Lingqiang Zhang: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics

DOI: https://doi.org/10.1038/s41467-018-07895-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

In atherosclerotic plaques, transformation of macrophages into foam cells is a key step in initiating the inflammatory response. Here Fan et al. show that casein kinase 2-interacting protein-1 (CKIP-1) limits foam cell formation and atherosclerosis by preventing expression of the scavenger receptor LOX-1 through REGγ-mediated degradation of Oct-1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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