Organic Afterglow Materials for Tumor Diagnosis and Therapy
Xiayi Chen,
Bin Li,
Baoli Yin,
Dong Xu,
Youjuan Wang
Affiliations
Xiayi Chen
The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China
Bin Li
The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China
Baoli Yin
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
Dong Xu
The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China
Youjuan Wang
The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China
Organic afterglow nanoparticles (OANs) represent a unique class of optical materials capable of sustaining luminescence after excitation cessation. Owing to their exceptional design flexibility, tunable optical properties, and favorable biosafety profiles, OAN-based afterglow imaging has emerged as an advanced modality in tumor diagnosis and therapy. These nanostructures demonstrate significant potential in guiding precision surgical interventions and real-time monitoring of tumor treatment, including photodynamic therapy, photothermal therapy, and immunotherapy. This review systematically analyzes and discusses the luminescence mechanisms of OANs under various excitation sources, with particular emphasis on recent developments in tumor detection and treatment. Additionally, we also discuss the current challenges and future perspectives of using these nanoparticles in this field.
