Distinct transcriptional roles for Histone H3-K56 acetylation during the cell cycle in Yeast

Abstract

H3K56Ac promotes nucleosome turnover at promoter-proximal locations and assembly of new nucleosomes during S phase. Here the authors find that H3K56Ac is both a genome-wide activator of transcription in yeast while also repressing promiscuous transcription that occurs after replication fork passage.