Nature Communications (Mar 2016)
Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
- Moritz Leppkes,
- Christian Maueröder,
- Sebastian Hirth,
- Stefanie Nowecki,
- Claudia Günther,
- Ulrike Billmeier,
- Susanne Paulus,
- Mona Biermann,
- Luis E. Munoz,
- Markus Hoffmann,
- Dane Wildner,
- Andrew L. Croxford,
- Ari Waisman,
- Kerri Mowen,
- Dieter E. Jenne,
- Veit Krenn,
- Julia Mayerle,
- Markus M. Lerch,
- Georg Schett,
- Stefan Wirtz,
- Markus F. Neurath,
- Martin Herrmann,
- Christoph Becker
Affiliations
- Moritz Leppkes
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Christian Maueröder
- Department of Medicine 3, University Clinics Erlangen, University of Erlangen-Nuremberg
- Sebastian Hirth
- Institute of Molecular Medicine, University Medicine of Johannes Gutenberg University
- Stefanie Nowecki
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Claudia Günther
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Ulrike Billmeier
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Susanne Paulus
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Mona Biermann
- Department of Medicine 3, University Clinics Erlangen, University of Erlangen-Nuremberg
- Luis E. Munoz
- Department of Medicine 3, University Clinics Erlangen, University of Erlangen-Nuremberg
- Markus Hoffmann
- Department of Medicine 3, University Clinics Erlangen, University of Erlangen-Nuremberg
- Dane Wildner
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Andrew L. Croxford
- Institute of Molecular Medicine, University Medicine of Johannes Gutenberg University
- Ari Waisman
- Institute of Molecular Medicine, University Medicine of Johannes Gutenberg University
- Kerri Mowen
- Department of Chemical Physiology, Scripps Institute
- Dieter E. Jenne
- Institute of Lung Biology and Disease, Comprehensive Pneumology Center
- Veit Krenn
- Department of Pathology, MVZ of Pathology
- Julia Mayerle
- Department of Medicine A, University Medicine Greifswald
- Markus M. Lerch
- Department of Medicine A, University Medicine Greifswald
- Georg Schett
- Department of Medicine 3, University Clinics Erlangen, University of Erlangen-Nuremberg
- Stefan Wirtz
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Markus F. Neurath
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- Martin Herrmann
- Department of Medicine 3, University Clinics Erlangen, University of Erlangen-Nuremberg
- Christoph Becker
- Department of Medicine 1, University Clinics Erlangen, University of Erlangen-Nuremberg
- DOI
- https://doi.org/10.1038/ncomms10973
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans.
