Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP
<sup>C</sup>
and Other Host-Specific Factors

Juan Carlos Espinosa; Olivier Andreoletti; Alba Marín-Moreno; Severine Lugan; Patricia Aguilar-Calvo; Hervé Cassard; Patricia Lorenzo; Jean-Yves Douet; Ana Villa-Díaz; Naima Aron; Irene Prieto; Alvina Huor; Juan María Torres

doi:10.1128/mBio.03508-20

mBio (Apr 2021)

Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP <sup>C</sup> and Other Host-Specific Factors

Juan Carlos Espinosa,
Olivier Andreoletti,
Alba Marín-Moreno,
Severine Lugan,
Patricia Aguilar-Calvo,
Hervé Cassard,
Patricia Lorenzo,
Jean-Yves Douet,
Ana Villa-Díaz,
Naima Aron,
Irene Prieto,
Alvina Huor,
Juan María Torres

Affiliations

Juan Carlos Espinosa: ORCiD; Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain
Olivier Andreoletti: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
Alba Marín-Moreno: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain
Severine Lugan: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
Patricia Aguilar-Calvo: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain
Hervé Cassard: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
Patricia Lorenzo: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain
Jean-Yves Douet: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
Ana Villa-Díaz: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain
Naima Aron: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
Irene Prieto: Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain
Alvina Huor: INRA, UMR 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France
Juan María Torres: ORCiD; Centro de Investigación en Sanidad Animal (CISA-INIA), Madrid, Spain

DOI: https://doi.org/10.1128/mBio.03508-20
Journal volume & issue: Vol. 12, no. 2

Abstract

Read online

Prion propagation can be interfered with by the expression of a second prion protein in the host. In the present study, we investigated prion propagation in a host expressing two different prion protein genes.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal