Nature Communications (Mar 2016)
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
- Defang Li,
- Jin Liu,
- Baosheng Guo,
- Chao Liang,
- Lei Dang,
- Cheng Lu,
- Xiaojuan He,
- Hilda Yeuk-Siu Cheung,
- Liang Xu,
- Changwei Lu,
- Bing He,
- Biao Liu,
- Atik Badshah Shaikh,
- Fangfei Li,
- Luyao Wang,
- Zhijun Yang,
- Doris Wai-Ting Au,
- Songlin Peng,
- Zongkang Zhang,
- Bao-Ting Zhang,
- Xiaohua Pan,
- Airong Qian,
- Peng Shang,
- Lianbo Xiao,
- Baohong Jiang,
- Chris Kong-Chu Wong,
- Jiake Xu,
- Zhaoxiang Bian,
- Zicai Liang,
- De-an Guo,
- Hailong Zhu,
- Weihong Tan,
- Aiping Lu,
- Ge Zhang
Affiliations
- Defang Li
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Jin Liu
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Baosheng Guo
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Chao Liang
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Lei Dang
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Cheng Lu
- Institute of Integrated Bioinfomedicine and Translational Science, School of Chinese Medicine, Hong Kong Baptist University
- Xiaojuan He
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Hilda Yeuk-Siu Cheung
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Liang Xu
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Changwei Lu
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Bing He
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Biao Liu
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Atik Badshah Shaikh
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Fangfei Li
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Luyao Wang
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Zhijun Yang
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Doris Wai-Ting Au
- Department of Biology and Chemistry, City University of Hong Kong
- Songlin Peng
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Zongkang Zhang
- School of Chinese Medicine, Faculty of Medicine, Chinese University of Hong Kong
- Bao-Ting Zhang
- School of Chinese Medicine, Faculty of Medicine, Chinese University of Hong Kong
- Xiaohua Pan
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Airong Qian
- Hong Kong Baptist University–Northwestern Polytechnical University Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space
- Peng Shang
- Hong Kong Baptist University–Northwestern Polytechnical University Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space
- Lianbo Xiao
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Baohong Jiang
- Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Chris Kong-Chu Wong
- Department of Biology, Hong Kong Baptist University
- Jiake Xu
- Molecular Laboratory, School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6907, Australia
- Zhaoxiang Bian
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Zicai Liang
- Research Group of Bone and Joint Diseases, HKBU Institute of Science and Technology
- De-an Guo
- Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Hailong Zhu
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Weihong Tan
- Hong Kong Baptist University Branch of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University
- Aiping Lu
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- Ge Zhang
- Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University
- DOI
- https://doi.org/10.1038/ncomms10872
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
In previous studies the authors discovered that miR-214 inhibits osteoblastic bone formation. Here they extend on these findings, using ovariectomized mice and samples from patients with bone fractures, to show that miR-214 is a mediator of osteoclast-osteoblast crosstalk.
