Nature Communications (Oct 2018)
Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
- Marco L. Hennrich,
- Natalie Romanov,
- Patrick Horn,
- Samira Jaeger,
- Volker Eckstein,
- Violetta Steeples,
- Fei Ye,
- Ximing Ding,
- Laura Poisa-Beiro,
- Mang Ching Lai,
- Benjamin Lang,
- Jacqueline Boultwood,
- Thomas Luft,
- Judith B. Zaugg,
- Andrea Pellagatti,
- Peer Bork,
- Patrick Aloy,
- Anne-Claude Gavin,
- Anthony D. Ho
Affiliations
- Marco L. Hennrich
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Natalie Romanov
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Patrick Horn
- Molecular Medicine Partnership Unit (MMPU)
- Samira Jaeger
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Volker Eckstein
- Department of Medicine V, Heidelberg University
- Violetta Steeples
- Radcliffe Department of Medicine, University of Oxford and Oxford BRC Haematology Theme
- Fei Ye
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Ximing Ding
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Laura Poisa-Beiro
- Molecular Medicine Partnership Unit (MMPU)
- Mang Ching Lai
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Benjamin Lang
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Jacqueline Boultwood
- Radcliffe Department of Medicine, University of Oxford and Oxford BRC Haematology Theme
- Thomas Luft
- Department of Medicine V, Heidelberg University
- Judith B. Zaugg
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Andrea Pellagatti
- Radcliffe Department of Medicine, University of Oxford and Oxford BRC Haematology Theme
- Peer Bork
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Patrick Aloy
- Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
- Anne-Claude Gavin
- European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit
- Anthony D. Ho
- Molecular Medicine Partnership Unit (MMPU)
- DOI
- https://doi.org/10.1038/s41467-018-06353-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation.
