Clinical analysis of medication related osteonecrosis of the jaws: A growing severe complication in China

Qizhang Wang; Jiyuan Liu; Shuqun Qi; Xuejuan Liao; Dazhong Liu; Jian Pan

Journal of Dental Sciences (Sep 2018)

Clinical analysis of medication related osteonecrosis of the jaws: A growing severe complication in China

Qizhang Wang,
Jiyuan Liu,
Shuqun Qi,
Xuejuan Liao,
Dazhong Liu,
Jian Pan

Affiliations

Qizhang Wang: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
Jiyuan Liu: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
Shuqun Qi: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
Xuejuan Liao: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China
Dazhong Liu: Xindu District Peoples Hospital of Chengdu, Sichuan Province, China
Jian Pan: State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province, China; Corresponding author. Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3rd, Renmin Nan Road. Chengdu, Sichuan, 610041, China.

Journal volume & issue: Vol. 13, no. 3
pp. 190 – 197

Abstract

Read online

Background/purpose: Medication-related osteonecrosis of the jaws (MRONJ) is an unusual but quite serious complication. However, its mechanism remains unclear, and its treatment protocol is still controversial. Materials and methods: Our study involved 201 osteonecrosis of the jaw (ONJ) patients from September 2006 to March 2017. We analyzed risk factors, clinical characteristics, treatment, etc., by comparing MRONJ with other ONJs. Results: Among 201 patients, MRONJ accounted for 14.71% and it presented a consistent increase tendency. In comparison with other ONJs, we considered advanced age, maxilla lesion, diabetes mellitus, tooth extraction, especially multi-teeth extraction as risk factors (P 0.05). 81.3% patients with advanced stage showed complete or partial healing lesions after surgery. Conclusion: Advanced age, maxilla lesion, diabetes mellitus, tooth extraction seem to be important triggering factors for MRONJ. Clinicians and surgeons should pay attention to maxillary lesions as it is related to severe symptoms and unfavorable prognosis. Once diagnosed as MRONJ, surgery is an effective treatment for patients with advanced stage. Keywords: Bisphosphate, Osteonecrosis, Risk factor, Treatment

Published in Journal of Dental Sciences

ISSN: 1991-7902 (Print)
Publisher: Elsevier
Country of publisher: Taiwan, Province of China
LCC subjects: Medicine: Dentistry
Website: http://www.journals.elsevier.com/journal-of-dental-sciences/

About the journal