Nature Communications (Jul 2021)
Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
- Min-Min Lou,
- Xiao-Qiang Tang,
- Guang-Ming Wang,
- Jia He,
- Fang Luo,
- Ming-Feng Guan,
- Fei Wang,
- Huan Zou,
- Jun-Ying Wang,
- Qun Zhang,
- Ming-Jian Xu,
- Qi-Li Shi,
- Li-Bing Shen,
- Guo-Ming Ma,
- Yi Wu,
- Yao-Yang Zhang,
- Ai-bin Liang,
- Ting-Hua Wang,
- Liu-Lin Xiong,
- Jian Wang,
- Jun Xu,
- Wen-Yuan Wang
Affiliations
- Min-Min Lou
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Xiao-Qiang Tang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Guang-Ming Wang
- East Hospital, Tongji University School of Medicine
- Jia He
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Fang Luo
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Ming-Feng Guan
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Fei Wang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Huan Zou
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Jun-Ying Wang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Qun Zhang
- Department of Rehabilitation Medicine, Huashan Hospital, Fudan University
- Ming-Jian Xu
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Qi-Li Shi
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Li-Bing Shen
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Guo-Ming Ma
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Yi Wu
- Department of Rehabilitation Medicine, Huashan Hospital, Fudan University
- Yao-Yang Zhang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- Ai-bin Liang
- Postdoctoral Station of Clinical Medicine, Shanghai Tongji Hospital, Tongji University School of Medicine
- Ting-Hua Wang
- Animal Center of Zoology, Institute of Neuroscience, Kunming medical University
- Liu-Lin Xiong
- Animal Center of Zoology, Institute of Neuroscience, Kunming medical University
- Jian Wang
- Research Center for Aging and Medicine, Huashan Hospital, Fudan University
- Jun Xu
- East Hospital, Tongji University School of Medicine
- Wen-Yuan Wang
- Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese academy of Science
- DOI
- https://doi.org/10.1038/s41467-021-24236-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Long noncoding RNAs (lncRNAs) are known to regulate the DNA damage response (DDR), however their role in the brain is less well studied. Here, the authors demonstrate a neuron-specific role for Brain Specific DNA-damage Related lncRNA1 (BS-DRL1) and show BS-DRL1 modulates DDR by interacting with HMGB1 in a cell-type specific manner.
