Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

Abstract

During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.