Nature Communications (Dec 2017)

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

  • Shan He,
  • Yongnian Liu,
  • Lijun Meng,
  • Hongxing Sun,
  • Ying Wang,
  • Yun Ji,
  • Janaki Purushe,
  • Pan Chen,
  • Changhong Li,
  • Jozef Madzo,
  • Jean-Pierre Issa,
  • Jonathan Soboloff,
  • Ran Reshef,
  • Bethany Moore,
  • Luca Gattinoni,
  • Yi Zhang

DOI
https://doi.org/10.1038/s41467-017-02187-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.