COMMON VARIABLE IMMUNODEFICIENCY

Abstract

Common variable immunodeficiency (CVID) is a form of severe antibody deficiency with an estimated prevalence of 1 in 25,000 to 1 in 100,000. The disorder apparently results from currently undefined immune deregulations resulting in failed B-cell differentiation with impaired secretion of immunoglobulins. A 5-year female presented with fever, cough and shortness of breath at rest. Past medical history of incision and drainage for empyema followed by decortications before 2 years were there. Physical examination was significant bilateral crepitation and bronchial breathing. Laboratory data were significant for leukocytosis. The patient was diagnosed with CVID & started on four week regimen of IVIg. This case emphasizes the need for a high index of clinical suspicion for CVID in patients presenting with recurrent sinopulmonary infections.

Keywords

• Immunodeficiency
• sinopulmonary
• intravenous immunoglobulin
• antibody