Nature Communications (May 2019)

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

  • Judit Domingo-Prim,
  • Martin Endara-Coll,
  • Franziska Bonath,
  • Sonia Jimeno,
  • Rosario Prados-Carvajal,
  • Marc R. Friedländer,
  • Pablo Huertas,
  • Neus Visa

DOI
https://doi.org/10.1038/s41467-019-10153-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The exosome is a ribonucleolytic complex that plays part in RNA processing and degradation. Here, the authors reveal an RNA clearance event in homologous recombination and show the function of EXOSC10, a component of the exosome, in the homeostasis of RNA molecules synthesized at DSB sites.