Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

Chery A. Whipple; Arthur D. Lander; Murray Korc

doi:10.1100/tsw.2008.152

The Scientific World Journal (Jan 2008)

Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

Chery A. Whipple,
Arthur D. Lander,
Murray Korc

Affiliations

Chery A. Whipple: Department of Medicine, Department of Pharmacology and Toxicology, and the Norris Cotton Comprehensive Cancer Center, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Hanover, NH, USA
Arthur D. Lander: Department of Development and Cell Biology, University of California, Irvine, USA
Murray Korc: Department of Medicine, Department of Pharmacology and Toxicology, and the Norris Cotton Comprehensive Cancer Center, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Hanover, NH, USA

DOI: https://doi.org/10.1100/tsw.2008.152
Journal volume & issue: Vol. 8
pp. 1250 – 1253

Abstract

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The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

Published in The Scientific World Journal

ISSN: 2356-6140 (Print); 1537-744X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Technology; Medicine; Science
Website: https://onlinelibrary.wiley.com/journal/8086

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