Uric Acid and Clinical Outcomes in Young Patients with Ischemic Stroke

Abstract

Yanfang Liu,1– 3,* Xinmin Liu,1,2,* Jiaokun Jia,1– 3 Jiahuan Guo,1,2 Guangshuo Li,1,2 Xingquan Zhao1– 4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of China; 3Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xingquan Zhao, Email [email protected] and Purpose: There is limited available evidence for the relationship between uric acid (UA) levels and ischemic stroke in young adults. We aimed to explore the association between UA levels and acute ischemic stroke (AIS) in young patients.Materials and Methods: This was a prospective and observational study. We recruited young patients aged 18– 45 years with AIS at our tertiary hospital. Patients were categorized into four groups according to quartiles of UA levels. The primary outcome was functional outcome at 3 months. The secondary outcomes included stroke severity, in-hospital complications, and functional outcome at discharge. Modified Rankin Scale (mRS) scores were used to assess functional outcome as poor (mRS=2-6) or favorable(mRS=0-1).Results: A total of 636 patients were enrolled in the current analysis. The four groups were defined as follows: Q1≤ 289.8 μmol/L, 289.8 μmol/ L

Keywords

• uric acid
• young ischemic stroke
• outcome
• stroke severity
• complication