Primary bone tumors can be either benign or malignant considering their natural history and cellular morphology. Benign bone tumors are much more frequent than malignant ones although some of them like giant cell tumor of bone can behave just like a malignant one that means has the capacity for massive local destruction and remote metastasis. Giant cell tumor of bone in adult people has a very strong and diagnostic predilection for epiphysial location in long bones. Very few cases have been so far reported for a giant cell tumor of bone with non-epiphysial location in a long bone.
