A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

Ekaterini Platanitis; Duygu Demiroz; Anja Schneller; Katrin Fischer; Christophe Capelle; Markus Hartl; Thomas Gossenreiter; Mathias Müller; Maria Novatchkova; Thomas Decker

doi:10.1038/s41467-019-10970-y

Nature Communications (Jul 2019)

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

Ekaterini Platanitis,
Duygu Demiroz,
Anja Schneller,
Katrin Fischer,
Christophe Capelle,
Markus Hartl,
Thomas Gossenreiter,
Mathias Müller,
Maria Novatchkova,
Thomas Decker

Affiliations

Ekaterini Platanitis: Max Perutz Labs (MPL), University of Vienna
Duygu Demiroz: Max Perutz Labs (MPL), University of Vienna
Anja Schneller: Max Perutz Labs (MPL), University of Vienna
Katrin Fischer: Max Perutz Labs (MPL), University of Vienna
Christophe Capelle: Max Perutz Labs (MPL), University of Vienna
Markus Hartl: Max Perutz Labs (MPL), University of Vienna
Thomas Gossenreiter: Max Perutz Labs (MPL), University of Vienna
Mathias Müller: Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
Maria Novatchkova: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Thomas Decker: Max Perutz Labs (MPL), University of Vienna

DOI: https://doi.org/10.1038/s41467-019-10970-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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A rapid cellular response to interferons (IFNs) is critical for establishing antimicrobial immunity, but how cells switch from from homeostasis to IFN signaling is not fully understood. Here, the authors provide evidence that IFNs induce gene expression by alternating subunits of transcription factor ISGF3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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