Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Xiuye Wang; Thomas Hennig; Adam W. Whisnant; Florian Erhard; Bhupesh K. Prusty; Caroline C. Friedel; Elmira Forouzmand; William Hu; Luke Erber; Yue Chen; Rozanne M. Sandri-Goldin; Lars Dölken; Yongsheng Shi

doi:10.1038/s41467-019-14109-x

Nature Communications (Jan 2020)

Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Xiuye Wang,
Thomas Hennig,
Adam W. Whisnant,
Florian Erhard,
Bhupesh K. Prusty,
Caroline C. Friedel,
Elmira Forouzmand,
William Hu,
Luke Erber,
Yue Chen,
Rozanne M. Sandri-Goldin,
Lars Dölken,
Yongsheng Shi

Affiliations

Xiuye Wang: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine
Thomas Hennig: Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg
Adam W. Whisnant: Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg
Florian Erhard: Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg
Bhupesh K. Prusty: Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg
Caroline C. Friedel: Institute of Informatics, Ludwig-Maximilians-Universität München
Elmira Forouzmand: Institute for Genomics and Bioinformatics, University of California, Irvine
William Hu: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine
Luke Erber: Department of Biochemistry, Molecular Biology, and Biophysics, College of Biological Sciences, University of Minnesota
Yue Chen: Department of Biochemistry, Molecular Biology, and Biophysics, College of Biological Sciences, University of Minnesota
Rozanne M. Sandri-Goldin: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine
Lars Dölken: Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg
Yongsheng Shi: Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine

DOI: https://doi.org/10.1038/s41467-019-14109-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRNA 3’ processing factor CPSF and disruption of the processing complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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