The Role of Circular RNAs in DNA Damage Response and Repair

Angelos Papaspyropoulos; Orsalia Hazapis; Nefeli Lagopati; Aikaterini Polyzou; Anastasios D. Papanastasiou; Michalis Liontos; Vassilis G. Gorgoulis; Athanassios Kotsinas

doi:10.3390/cancers13215352

Cancers (Oct 2021)

The Role of Circular RNAs in DNA Damage Response and Repair

Angelos Papaspyropoulos,
Orsalia Hazapis,
Nefeli Lagopati,
Aikaterini Polyzou,
Anastasios D. Papanastasiou,
Michalis Liontos,
Vassilis G. Gorgoulis,
Athanassios Kotsinas

Affiliations

Angelos Papaspyropoulos: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
Orsalia Hazapis: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
Nefeli Lagopati: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
Aikaterini Polyzou: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
Anastasios D. Papanastasiou: Department of Biomedical Sciences, University of West Attica, GR-12462 Athens, Greece
Michalis Liontos: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
Vassilis G. Gorgoulis: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece
Athanassios Kotsinas: Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, Greece

DOI: https://doi.org/10.3390/cancers13215352
Journal volume & issue: Vol. 13, no. 21
p. 5352

Abstract

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Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs that are abundantly expressed in the cell. CircRNAs have the capacity to regulate gene expression by interacting with regulatory proteins and/or other classes of RNAs. While a vast number of circRNAs have been discovered, the majority still remains poorly characterized. Particularly, there is no detailed information on the identity and functional role of circRNAs that are transcribed from genes encoding components of the DNA damage response and repair (DDRR) network. In this article, we not only review the available published information on DDRR-related circRNAs, but also conduct a bioinformatic analysis on data obtained from public repositories to uncover deposited, yet uncharacterized circRNAs derived from components of the DDRR network. Finally, we interrogate for potential targets that are regulated by this class of molecules and look into potential functional implications.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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