TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice

Deqiang Ding; Jiali Liu; Uros Midic; Yingjie Wu; Kunzhe Dong; Ashley Melnick; Keith E. Latham; Chen Chen

doi:10.1038/s41467-017-02622-w

Nature Communications (Jan 2018)

TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice

Deqiang Ding,
Jiali Liu,
Uros Midic,
Yingjie Wu,
Kunzhe Dong,
Ashley Melnick,
Keith E. Latham,
Chen Chen

Affiliations

Deqiang Ding: Department of Animal Science, Michigan State University
Jiali Liu: Department of Animal Science, Michigan State University
Uros Midic: Department of Animal Science, Michigan State University
Yingjie Wu: Department of Animal Science, Michigan State University
Kunzhe Dong: USDA, Agricultural Research Service, Avian Disease and Oncology Laboratory
Ashley Melnick: Department of Animal Science, Michigan State University
Keith E. Latham: Department of Animal Science, Michigan State University
Chen Chen: Department of Animal Science, Michigan State University

DOI: https://doi.org/10.1038/s41467-017-02622-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Pachytene piRNAs are abundant piRNAs in mammalian adult testes but their biogenesis pathway is not fully understood. Here, the authors identify TDRD5 as a piRNA biogenesis factor in mice, showing that it binds piRNA precursors and promotes pachytene piRNA production from specific transcript regions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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