Frontiers in Endocrinology (Dec 2024)

Adult height in girls with idiopathic central precocious puberty treated with triptorelin

  • Raquel Corripio,
  • Leandro Soriano-Guillén,
  • Francisco-Javier Herrero,
  • Lidia Castro-Feijoó,
  • Aránzazu Escribano,
  • Paula Sol-Ventura,
  • Rafael Espino,
  • Amaia Vela,
  • José-Ignacio Labarta,
  • The Spanish PUBERE Group,
  • Jesús Argente,
  • Ignacio Díez López,
  • Rafael Ruiz Cano,
  • José Pastor Rosado,
  • Diego Esteban de Sotto,
  • Nuria Cabrinety Perez,
  • Diego Yeste Fernández,
  • Larisa Suárez Ortega,
  • Mariona Bonet Alcaina,
  • Rosa Martín Ramos,
  • Gertrudis Martí Aromir,
  • Rosangela Tomasini,
  • Gemma Carreras González,
  • María Victoria Borrás Pérez,
  • Meritxell Torrabías Rodas,
  • Montserrat Roqueta Sureda,
  • Marta Murillo Valles,
  • Francisco Javier Arroyo Díez,
  • Jesús González de Buitrago,
  • José Luis Lechuga Campoy,
  • Alfonso Lechuga Sancho,
  • Ramón Cañete Estrada,
  • Lidia Castro Feijóo,
  • Jesús Barreiro Conde,
  • Paloma Cabanas Rodríguez,
  • Jordi Bosch Muñoz,
  • Alicia Cepedano Dans,
  • Mª Teresa Muñoz Calvo,
  • Julio Guerrero Fernández,
  • Rafael Yturriaga Matarranz,
  • Elena Gallego Gómez,
  • Jaime Sánchez del Pozo,
  • Purificación Ros Pérez,
  • Joaquín Ramírez Fernández,
  • Mª Dolores Rodríguez Arnao,
  • Amparo Rodríguez Sánchez,
  • Juan Pedro López Siguero,
  • Maria Jose Martinez-Aedo Ollero,
  • Antonio Gutiérrez Macias,
  • José María Martos Tello,
  • María Chueca Guindulain,
  • Cristina Azcona Sanjulián,
  • Pablo Guerrero,
  • Isolina Riaño Galán,
  • Sofía Quinteiro González,
  • José Manuel Rial Rodríguez,
  • Juan Pedro González Díaz,
  • Rafael Espino Aguilar,
  • Luis López-Canti,
  • Raquel Monné Gelonch,
  • Jesús Martín Calama,
  • Lidia Blasco Gonzalez,
  • Juan Alcón SáezJosé,
  • Amparo Plasencia Couchoud,
  • Luis Castaño González,
  • Pedro Martul Tobío,
  • Itxaso Rica Etxebarría,
  • Concepción Fernández Ramos,
  • Mª. Zaragoza Lou Francés Gracia,
  • Manuel Ruiz-Echarri Zalaya,
  • Gloria Bueno Lozano

DOI
https://doi.org/10.3389/fendo.2024.1498726
Journal volume & issue
Vol. 15

Abstract

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ObjectiveIdiopathic central precocious puberty (CPP) precipitates epiphyseal fusion of growth plates in long bones, leading to reduced adult stature. Gonadotropin-releasing hormone analogues (GnRHa) are the treatment of choice for idiopathic CPP, but their benefit on height gain is unclear. We aimed to elucidate the effects of GnRHa treatment on adult height in girls with idiopathic CPP.DesignThis prospective observational descriptive study analyzed data of girls with idiopathic CPP diagnosed at 55 centers in Spain between January 1, 1998 and December 31, 2012 included in the Spanish Society for Pediatric Endocrinology’s national registry.MethodsWe included girls with idiopathic CPP (thelarche < 8 years, positive LHRH stimulation test, bone age > 1 year older than chronological age, and normal brain imaging) treated with triptorelin (3.75 mg monthly, adjusted according to LHRH test results and clinical findings). We assessed weight, height, BMI, and secondary sexual characteristics every 6 months and bone age every 12 months until adult height (AH) was attained. The primary outcome was the difference between AH and target height (TH).ResultsA total of 465 girls (18.90% adopted) were included; we analyzed data recorded at treatment end in 358 girls and at AH in 216. Mean difference between AH and TH was -1.5 (95%CI: -2.56− -0.45) cm and between AH and PAH 2,57 (95%CI:-3.56− -1.58) cm.ConclusionsGnRHa treatment helps preserve genetic growth potential in girls with idiopathic CPP.

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