Molecular basis for heat desensitization of TRPV1 ion channels

Lei Luo; Yunfei Wang; Bowen Li; Lizhen Xu; Peter Muiruri Kamau; Jie Zheng; Fan Yang; Shilong Yang; Ren Lai

doi:10.1038/s41467-019-09965-6

Nature Communications (May 2019)

Molecular basis for heat desensitization of TRPV1 ion channels

Lei Luo,
Yunfei Wang,
Bowen Li,
Lizhen Xu,
Peter Muiruri Kamau,
Jie Zheng,
Fan Yang,
Shilong Yang,
Ren Lai

Affiliations

Lei Luo: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology
Yunfei Wang: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology
Bowen Li: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology
Lizhen Xu: Key Laboratory of Medical Neurobiology, Department of Biophysics and Kidney Disease Center, First Affiliated Hospital, Institute of Neuroscience, National Health Commission and Chinese Academy of Medical Sciences, Zhejiang University School of Medicine
Peter Muiruri Kamau: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology
Jie Zheng: Department of Physiology and Membrane Biology, University of California
Fan Yang: Key Laboratory of Medical Neurobiology, Department of Biophysics and Kidney Disease Center, First Affiliated Hospital, Institute of Neuroscience, National Health Commission and Chinese Academy of Medical Sciences, Zhejiang University School of Medicine
Shilong Yang: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology
Ren Lai: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology

DOI: https://doi.org/10.1038/s41467-019-09965-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

The heat-sensitive ion channel TRPV1 is essential to temperature sensing in mammals and other animals. Here the authors find that the platypus form of TRPV1 does not desensitize, identify the mechanism underlying this property, and show that knock-in of this form of the receptor in mice leads to deficits in heat sensitivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal