Nature Communications (Jan 2020)

CaSpER identifies and visualizes CNV events by integrative analysis of single-cell or bulk RNA-sequencing data

  • Akdes Serin Harmanci,
  • Arif O. Harmanci,
  • Xiaobo Zhou

DOI
https://doi.org/10.1038/s41467-019-13779-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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RNA-sequencing is mostly used to assess gene expression; however, it can also give information about genetic variants. Here, the authors present CaSpER, a statistical framework that utilises RNA-sequencing reads to identify and visualise CNV events by integrating transcriptome-wide expression and allelic shift profiles.