mBio
(Jun 2021)
A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei
Manuel Saldivia,
Adam J. M. Wollman,
Juliana B. T. Carnielli,
Nathaniel G. Jones,
Mark C. Leake,
Christopher Bower-Lepts,
Srinivasa P. S. Rao,
Jeremy C. Mottram
Affiliations
Manuel Saldivia
ORCiD York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom
Adam J. M. Wollman
ORCiD York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom
Juliana B. T. Carnielli
ORCiD York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom
Nathaniel G. Jones
ORCiD York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom
Mark C. Leake
ORCiD York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom
Christopher Bower-Lepts
York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom
Srinivasa P. S. Rao
ORCiD Novartis Institute for Tropical Diseases, Emeryville, California, USA
Jeremy C. Mottram
ORCiD York Biomedical Research Institute, Department of Biology, University of York, Heslington, United Kingdom
DOI
https://doi.org/10.1128/mBio.00687-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
In eukaryotic cells, kinetochores are large protein complexes that link chromosomes to dynamic microtubule tips, ensuring proper segregation and genomic stability during cell division. Several proteins tightly coordinate kinetochore functions, including the protein kinase aurora kinase B.
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