Propofol Related Infusion Syndrome: A Subtle Adversary

Abstract

Propofol Related Infusion Syndrome (PRIS) was first described in 1998. It has a strange collection of symptoms, including marked bradycardia, persistent, recalcitrant metabolic acidosis, liver enlargement, rhabdomyolysis, and lipemic blood. We present two recent patients who appeared to have had PRIS. Creatinine kinase seems to be an early detector of PRIS. If PRIS is recognized early, this complex metabolic process seems to be completely reversible.

Keywords

• propofol
• propofol related infusion syndrome
• metabolic acidosis
• rhabdomyolysis
• pris