Nature Communications (Apr 2022)
Genetic analysis of over half a million people characterises C-reactive protein loci
- Saredo Said,
- Raha Pazoki,
- Ville Karhunen,
- Urmo Võsa,
- Symen Ligthart,
- Barbara Bodinier,
- Fotios Koskeridis,
- Paul Welsh,
- Behrooz Z. Alizadeh,
- Daniel I. Chasman,
- Naveed Sattar,
- Marc Chadeau-Hyam,
- Evangelos Evangelou,
- Marjo-Riitta Jarvelin,
- Paul Elliott,
- Ioanna Tzoulaki,
- Abbas Dehghan
Affiliations
- Saredo Said
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Raha Pazoki
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Ville Karhunen
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Urmo Võsa
- Estonian Genome Centre, Institute of Genomics, University of Tartu
- Symen Ligthart
- Department of Intensive Care, University Hospital Antwerp
- Barbara Bodinier
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Fotios Koskeridis
- Department of Hygiene and Epidemiology, University of Ioannina Medical School
- Paul Welsh
- Institute of Cardiovascular and Medical Sciences, University of Glasgow
- Behrooz Z. Alizadeh
- Department of Epidemiology, University of Groningen and University Medical Centre Groningen
- Daniel I. Chasman
- Division of Preventive Medicine, Brigham & Women’s Hospital
- Naveed Sattar
- Institute of Cardiovascular and Medical Sciences, University of Glasgow
- Marc Chadeau-Hyam
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Evangelos Evangelou
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Marjo-Riitta Jarvelin
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Paul Elliott
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Ioanna Tzoulaki
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- Abbas Dehghan
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-022-29650-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Inflammation is associated with a variety of diseases. Here, the authors identify 266 genetic loci associated with C-reactive protein levels, a marker of inflammation, in >500,000 Europeans, along with associated pathways, clinical outcomes and potential causal associations with disease.
