Otolaryngology Case Reports (Sep 2022)
HPV related sino-nasal SCC of in pediatric female patient: A case report
Abstract
Sino-nasal cancers are considered a rare entity of malignancy, even rarer in the pediatrics population, we are presenting a case of 10 years old female patient who presented with a one-year history of unilateral epistaxis, physical examination showed an exophytic fleshy mass, imaging modality showed an unusual pathology of nasal mass. Background: Malignant tumors of the Sino-nasal cavities are considered rare the incidence is up to 1 per 100000 per year, and they constitute 1% of all cancers and around 5% of all head and neck cancers, squamous cell carcinoma (SCC) counts around 65% of all Sino-nasal cancers and tend to have a precursor pre-malignant lesion.Cigarette smoking, alcohol, and HPV are considered the main risk factors for different head and neck cancers, HPV has been linked to oral SCC with prognostic implications, despite the decline in smokers from the 80s to the beginning of the 2000s, the incidence of HPV linked SCC is interestingly increased.Smoking and alcohol were identified as risk factors for sino-nasal SCC, the relation between HPV and Sino-nasal SCC is not well established due to the rarity of these tumors and only around 20% of them were HPV positive [1].Pediatrics sinonasal malignancy are considered rare and are associated with poor prognosis, and usually they are presenting late due to overlapping nonspecific signs and symptoms [2].
