Are redox changes a critical switch for mitotic progression?

Abstract

Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.

Keywords

• aurka
• redox regulation
• mitosis
• kinase activation
• mitotic kinase