FEATURES OF LIPID PEROXIDATION PROCESS IN NORMAL CONDITIONS AND IN VARIOUS PATHOLOGICAL CONDITIONS IN CHILDREN (REVIEW OF LITERATURE)

Abstract

The article presents literature data on the lipid peroxidation and antioxidant defense system (LPO-AOD) under normal conditions. Lipid peroxidation is a physiological process which is constantly occurring in cell membranes and has a chain, free-radical mechanism. Free-radical reactions are involved in the repair of cell membranes, in the processes of phagocytosis and destruction of microorganisms, in conducting nerve impulses, in metabolism of various xenobiotics by liver and in biosynthesis of certain biologically active substances such as prostaglandins. Antioxidant defense neutralizes all kinds of radicals before they cause damage effect in a body. The imbalance in the LPO-AOD system causes oxidative stress. Nowadays research of this process in children of different age is very topical. Thus, reduction of the AOD intensity was proved in case of diseases such as arterial hypertension, chronic gastroduodenitis, influenza, cholelithiasis, pyelonephritis, metabolic syndrome, diabetes mellitus type 1. The conclusion on the necessity of inclusion of drugs with antioxidant action in the complex therapy of various pathological conditions along with the medical methods of treatment is made. Thus, the efficiency of the treatment of various diseases largely depends on the protection of the structure and function of cell membranes, and as a result the inclusion of drugs with antioxidant action in the treatment of almost any pathology in childhood is justified.

Keywords

• lipid peroxidation
• antioxidant defense
• childhood diseases