p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress

Binita Goswami; Deepika Ahuja; David Pastré; Partho Sarothi Ray

doi:10.1038/s42003-023-04507-9

Communications Biology (Jan 2023)

p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress

Binita Goswami,
Deepika Ahuja,
David Pastré,
Partho Sarothi Ray

Affiliations

Binita Goswami: Department of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur
Deepika Ahuja: Department of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur
David Pastré: SABNP, Univ Evry, INSERM U1204, Université Paris-Saclay
Partho Sarothi Ray: Department of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, Mohanpur

DOI: https://doi.org/10.1038/s42003-023-04507-9
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 17

Abstract

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miRNA-125b, a translational repressor of p53, undergoes initial HuR-mediated exosomal export in response to DNA damage, leading to p53 upregulation, which in turn induces transcription and processing of miR-125b causing inhibition of p53 expression.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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