Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system
Bobin Mi,
Yuan Xiong,
Samuel Knoedler,
Michael Alfertshofer,
Adriana C. Panayi,
Haixing Wang,
Sien Lin,
Gang Li,
Guohui Liu
Affiliations
Bobin Mi
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yuan Xiong
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Samuel Knoedler
Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School
Michael Alfertshofer
Division of Hand, Plastic and Aesthetic Surgery, Ludwig - Maximilian University Munich
Adriana C. Panayi
Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School
Haixing Wang
Department of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital
Sien Lin
Department of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital
Gang Li
Department of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital
Guohui Liu
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Abstract Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues, including the skeletal and immune systems. Recent studies have elucidated the intricate bidirectional interactions between these two systems. In this review, we provide a comprehensive synthesis of molecular mechanisms of cell ageing. We further discuss how age-related skeletal changes influence the immune system and the consequent impact of immune system alterations on the skeletal system. Finally, we highlight the clinical implications of these findings and propose potential strategies to promote healthy ageing and reduce pathologic deterioration of both the skeletal and immune systems.
