Nature Communications (May 2020)

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

  • Caitlin A. Nichols,
  • William J. Gibson,
  • Meredith S. Brown,
  • Jack A. Kosmicki,
  • John P. Busanovich,
  • Hope Wei,
  • Laura M. Urbanski,
  • Naomi Curimjee,
  • Ashton C. Berger,
  • Galen F. Gao,
  • Andrew D. Cherniack,
  • Sirano Dhe-Paganon,
  • Brenton R. Paolella,
  • Rameen Beroukhim

DOI
https://doi.org/10.1038/s41467-020-16399-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.