Nature Communications (Dec 2017)

Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme

  • Jennifer P. Newman,
  • Grace Y. Wang,
  • Kazuhiko Arima,
  • Shou P. Guan,
  • Michael R. Waters,
  • Webster K. Cavenee,
  • Edward Pan,
  • Edita Aliwarga,
  • Siao T. Chong,
  • Catherine Y. L. Kok,
  • Berwini B. Endaya,
  • Amyn A. Habib,
  • Tomohisa Horibe,
  • Wai H. Ng,
  • Ivy A. W. Ho,
  • Kam M. Hui,
  • Tomasz Kordula,
  • Paula Y. P. Lam

DOI
https://doi.org/10.1038/s41467-017-01392-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 17

Abstract

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Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferation.