Nature Communications (Dec 2017)
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
- Jennifer P. Newman,
- Grace Y. Wang,
- Kazuhiko Arima,
- Shou P. Guan,
- Michael R. Waters,
- Webster K. Cavenee,
- Edward Pan,
- Edita Aliwarga,
- Siao T. Chong,
- Catherine Y. L. Kok,
- Berwini B. Endaya,
- Amyn A. Habib,
- Tomohisa Horibe,
- Wai H. Ng,
- Ivy A. W. Ho,
- Kam M. Hui,
- Tomasz Kordula,
- Paula Y. P. Lam
Affiliations
- Jennifer P. Newman
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Grace Y. Wang
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Kazuhiko Arima
- Department of Biomolecular Sciences, Saga Medical School
- Shou P. Guan
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Michael R. Waters
- School of Medicine, Virginia Commonwealth University
- Webster K. Cavenee
- Ludwig Institute for Cancer Research
- Edward Pan
- Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center
- Edita Aliwarga
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Siao T. Chong
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Catherine Y. L. Kok
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Berwini B. Endaya
- School of Medical Science, Griffith Health Institute, Griffith University
- Amyn A. Habib
- Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center and the North Texas VA Medical Center
- Tomohisa Horibe
- Department of Pharmacoepidemiology, Kyoto University School of Public Health
- Wai H. Ng
- National Neuroscience Institute
- Ivy A. W. Ho
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Kam M. Hui
- Bek Chai Heah Laboratory of Cancer Genomics, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- Tomasz Kordula
- School of Medicine, Virginia Commonwealth University
- Paula Y. P. Lam
- Laboratory of Cancer Gene Therapy, Cellular and Molecular Research Division, Humphrey Oei Institute of Cancer Research, National Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-017-01392-9
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferation.
