The preventive effects of Saccharomyces boulardii against oxidative stress induced by lipopolysaccharide in rat brain
Fatemeh Babaei,
Ava Navidi-Moghaddam,
Ariyan Naderi,
Shiva Ghafghazi,
Mohammadreza Mirzababaei,
Leila Dargahi,
Ghazaleh Mohammadi,
Marjan Nassiri-Asl
Affiliations
Fatemeh Babaei
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ava Navidi-Moghaddam
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ariyan Naderi
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shiva Ghafghazi
Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammadreza Mirzababaei
Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Leila Dargahi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ghazaleh Mohammadi
Cellular and Molecular Research Center, Research Institute for Prevention of Non- Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran; Department of Molecular Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran; Corresponding author. Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin. P.O. Box: 3415613911, Iran.
Marjan Nassiri-Asl
Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author. Department of Pharmacology and Neurobiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, P.O. Box 19839-63113, Iran.
The brain is sensitive to oxidative stress, which can trigger microglial activation and neuroinflammation. Antioxidant therapies may provide neuroprotection against oxidative stress. In recent years antioxidant effects of probiotics and their possible mechanisms in oxidative stress-related models have been determined. In the current study, for the first time, we assessed the effects of Saccharomyces boulardii on oxidative stress provoked by lipopolysaccharide (LPS) in the rat brain. Four groups of animals were used, including the control, LPS, S. boulardii + LPS, and S. boulardii groups. All animals received either saline or S. boulardii (1010 CFU) by gavage for four weeks. Between days 14 and 22, all animals received either LPS (250 μg/kg) or saline by intraperitoneal (i.p.) injection. S. boulardii was able to inhibit lipid peroxidation and prevent the reduction of antioxidant levels, including glutathione and catalase in the model of oxidative stress induced by LPS in the rat hippocampus and cortex. Also, it increased the lowered ratio of glutathione/oxidized glutathione in both tissues. Serum levels of anti-inflammatory interleukin 10 (IL-10) and proinflammatory cytokines IL-6 and IL-8 increased and decreased, respectively. S. boulardii has potential antioxidant activities in oxidative stress-related model, possibly modulating gut microbiota, immune defense, and antioxidant enzyme activities that can be considered in preventing oxidative stress-related central nervous system (CNS) diseases.
