Oncocytic carcinoma of the parotid gland as a manifestation of Birt-Hogg-Dube syndrome

Eric L Chen, MD; Jason Siu, MD; Sarah Bastawrous, DO; Camtu D. Truong, MD; Lei Wu, MD

Radiology Case Reports (Apr 2023)

Oncocytic carcinoma of the parotid gland as a manifestation of Birt-Hogg-Dube syndrome

Eric L Chen, MD,
Jason Siu, MD,
Sarah Bastawrous, DO,
Camtu D. Truong, MD,
Lei Wu, MD

Affiliations

Eric L Chen, MD: Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195, USA
Jason Siu, MD: Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle WA, 98195, USA
Sarah Bastawrous, DO: Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195, USA
Camtu D. Truong, MD: Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle WA, 98195, USA
Lei Wu, MD: Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, WA 98195, USA; Corresponding author.

Journal volume & issue: Vol. 18, no. 4
pp. 1536 – 1543

Abstract

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Renal oncocytomas are commonly reported in association with Birt-Hogg-Dube (BHS) syndrome, while BHD-associated oncocytomas of the parotid gland are rare. To date, there have been only 11 cases of BHD-associated parotid gland oncocytoma, without a reported case of malignant transformation. We present the first reported case of oncocytic carcinoma of the parotid gland associated with BHD, with radiologic and histologic correlation. This case establishes that BHD-associated parotid oncocytic lesions, previously identified only as benign oncocytomas in the literature to date, can undergo malignant transformation, and should potentially be regarded with a higher index of suspicion and lower threshold for aggressive management.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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