mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

R. W. Hallowell; S. L. Collins; J. M. Craig; Y. Zhang; M. Oh; P. B. Illei; Y. Chan-Li; C. L. Vigeland; W. Mitzner; A. L. Scott; J. D. Powell; M. R. Horton

doi:10.1038/ncomms14208

Nature Communications (Jan 2017)

mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis

R. W. Hallowell,
S. L. Collins,
J. M. Craig,
Y. Zhang,
M. Oh,
P. B. Illei,
Y. Chan-Li,
C. L. Vigeland,
W. Mitzner,
A. L. Scott,
J. D. Powell,
M. R. Horton

Affiliations

R. W. Hallowell: Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
S. L. Collins: Department of Medicine, Johns Hopkins University School of Medicine
J. M. Craig: Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health
Y. Zhang: Department of Respiratory Diseases, Shanghai Pulmonary Hospital, Tongji University School of Medicine
M. Oh: Department of Oncology, Johns Hopkins University School of Medicine
P. B. Illei: Department of Pathology, Johns Hopkins University School of Medicine
Y. Chan-Li: Department of Medicine, Johns Hopkins University School of Medicine
C. L. Vigeland: Department of Medicine, Johns Hopkins University School of Medicine
W. Mitzner: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University
A. L. Scott: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University
J. D. Powell: Department of Oncology, Johns Hopkins University School of Medicine
M. R. Horton: Department of Medicine, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/ncomms14208
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

mTORC1 and mTORC2 are alternatively required for differentiation of T cells into Th1/Th17 or Th2 cells. Here the authors show mTORC2 signalling is also needed for IL-4-induced M2 activation with functional evidence provided by aN. brasiliensisinfection model and cold challenge to model adaptive thermogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal