Nature Communications (Aug 2022)
Proteolytic processing induces a conformational switch required for antibacterial toxin delivery
- Nicholas L. Bartelli,
- Victor J. Passanisi,
- Karolina Michalska,
- Kiho Song,
- Dinh Q. Nhan,
- Hongjun Zhou,
- Bonnie J. Cuthbert,
- Lucy M. Stols,
- William H. Eschenfeldt,
- Nicholas G. Wilson,
- Jesse S. Basra,
- Ricardo Cortes,
- Zainab Noorsher,
- Youssef Gabraiel,
- Isaac Poonen-Honig,
- Elizabeth C. Seacord,
- Celia W. Goulding,
- David A. Low,
- Andrzej Joachimiak,
- Frederick W. Dahlquist,
- Christopher S. Hayes
Affiliations
- Nicholas L. Bartelli
- Department of Chemistry and Biochemistry, University of California
- Victor J. Passanisi
- Department of Chemistry and Biochemistry, University of California
- Karolina Michalska
- Midwest Center for Structural Genomics, Argonne National Laboratory
- Kiho Song
- Biomolecular Science and Engineering Program, University of California
- Dinh Q. Nhan
- Department of Molecular, Cellular and Developmental Biology, University of California
- Hongjun Zhou
- Department of Chemistry and Biochemistry, University of California
- Bonnie J. Cuthbert
- Department of Molecular Biology & Biochemistry, University of California
- Lucy M. Stols
- Midwest Center for Structural Genomics, Argonne National Laboratory
- William H. Eschenfeldt
- Midwest Center for Structural Genomics, Argonne National Laboratory
- Nicholas G. Wilson
- Department of Chemistry and Biochemistry, University of California
- Jesse S. Basra
- Department of Chemistry and Biochemistry, University of California
- Ricardo Cortes
- Department of Chemistry and Biochemistry, University of California
- Zainab Noorsher
- Department of Chemistry and Biochemistry, University of California
- Youssef Gabraiel
- Department of Chemistry and Biochemistry, University of California
- Isaac Poonen-Honig
- Department of Chemistry and Biochemistry, University of California
- Elizabeth C. Seacord
- Department of Chemistry and Biochemistry, University of California
- Celia W. Goulding
- Department of Molecular Biology & Biochemistry, University of California
- David A. Low
- Biomolecular Science and Engineering Program, University of California
- Andrzej Joachimiak
- Midwest Center for Structural Genomics, Argonne National Laboratory
- Frederick W. Dahlquist
- Department of Chemistry and Biochemistry, University of California
- Christopher S. Hayes
- Biomolecular Science and Engineering Program, University of California
- DOI
- https://doi.org/10.1038/s41467-022-32795-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Contact-dependent growth inhibition (CDI) is an important mechanism of bacterial competition. Here, Bartelli et al. show that proteolytic processing of a CDI toxin induces a conformational switch required for translocation into target bacteria.
