Change in renin, cardiovascular and inflammatory markers over three years in a black and white population: the SABPA study

Abstract

Abstract Background To investigate if percentage change (%∆) in renin over a 3 year follow-up is associated with %∆ in cardiovascular and inflammatory markers in a low renin bi-ethnic group. Methods Blood pressure, active renin, C-reactive protein and interleukin-6 levels of 73 black and 81 white teachers were measured at baseline and after 3 years. Results In the black group, %∆ renin was inversely associated with %∆ systolic blood pressure (β = −0.27; p = 0.011). In the white group %∆ renin was inversely associated with %∆interleukin-6 (β = −0.24; p = 0.005). Conclusions These prospective results indicate that a decrease in renin over time is associated with an increase in blood pressure in a low renin black South African cohort.

Keywords

• Race
• C-reactive protein
• Hypertension
• Inflammation
• Interleukin-6
• Low renin