Thyroid Hormones and Cardiometabolic Risk Factors in Saudi Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

Abstract

Walaa Mohammed Saeed,1 Fahad Alsehli2 1Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Taibah University, Al Madinah Al Munawarah, Saudi Arabia; 2Pathology, King Salman Medical City, Madinah, Saudi ArabiaCorrespondence: Walaa Mohammed Saeed, Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Taibah University, 344, Postal Code 3000, Al Madinah Al Munawarah, Saudi Arabia, Tel [phone], Email [email protected]: The PCOS-thyroid nexus has recently drawn the focus of various investigations due to the prevalence of thyroid problems in PCOS. Additionally, risk factors for cardiovascular disease (CVD) are more prevalent in PCOS women. Therefore, we aim to assess the levels of thyroid hormones in Saudi females with polycystic ovary syndrome (PCOS) and to examine the correlation between cardiometabolic risk factors (CMRFs) and thyroid hormones in PCOS patients.Methods: A cross-sectional research with 200 PCOS-diagnosed female patients was conducted from April 2018 to April 2020. In addition to other anthropometric and serum biochemical markers, glycemic status, thyroid function test, lipid profiles, homocysteine, and C-reactive protein levels were detected in patients.Results: In PCOS, hypothyroidism is more common than hyperthyroidism (55 vs 27.5%, p = 0.05). While women with raised TSH (hypothyroidism) had a higher BMI, WC, FBG, and poorer HDL-C (p

Keywords

• thyroid disorder
• insulin resistance
• obesity
• polycystic ovary syndrome
• atherogenic index of plasma