Nature Communications (Oct 2020)

Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA

  • Gulfem D. Guler,
  • Yuhong Ning,
  • Chin-Jen Ku,
  • Tierney Phillips,
  • Erin McCarthy,
  • Christopher K. Ellison,
  • Anna Bergamaschi,
  • Francois Collin,
  • Paul Lloyd,
  • Aaron Scott,
  • Michael Antoine,
  • Wendy Wang,
  • Kim Chau,
  • Alan Ashworth,
  • Stephen R. Quake,
  • Samuel Levy

DOI
https://doi.org/10.1038/s41467-020-18965-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

Circulating DNA detected in plasma can be used for diagnostic purposes. Here, the authors show that the 5-hydroxymethyl cytosine biomarker from plasma-derived cell free DNA can be used to detect early stage pancreatic cancer.