Nature Communications (Mar 2018)

Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting

  • Marc Lenoir,
  • Cansel Ustunel,
  • Sandya Rajesh,
  • Jaswant Kaur,
  • Dimitri Moreau,
  • Jean Gruenberg,
  • Michael Overduin

DOI
https://doi.org/10.1038/s41467-018-03370-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Sorting nexin 3 (SNX3) is a phosphatidylinositol 3-phosphate binding protein that localizes to early endosomes. Here the authors use NMR to resolve SNX3′s membrane interactions, revealing that membrane binding is regulated through phosphorylation of a conserved serine by its lipid recognition site.