Nature Communications (Jan 2019)
A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia
- Kaustubh Adhikari,
- Javier Mendoza-Revilla,
- Anood Sohail,
- Macarena Fuentes-Guajardo,
- Jodie Lampert,
- Juan Camilo Chacón-Duque,
- Malena Hurtado,
- Valeria Villegas,
- Vanessa Granja,
- Victor Acuña-Alonzo,
- Claudia Jaramillo,
- William Arias,
- Rodrigo Barquera Lozano,
- Paola Everardo,
- Jorge Gómez-Valdés,
- Hugo Villamil-Ramírez,
- Caio C. Silva de Cerqueira,
- Tábita Hunemeier,
- Virginia Ramallo,
- Lavinia Schuler-Faccini,
- Francisco M. Salzano,
- Rolando Gonzalez-José,
- Maria-Cátira Bortolini,
- Samuel Canizales-Quinteros,
- Carla Gallo,
- Giovanni Poletti,
- Gabriel Bedoya,
- Francisco Rothhammer,
- Desmond J. Tobin,
- Matteo Fumagalli,
- David Balding,
- Andrés Ruiz-Linares
Affiliations
- Kaustubh Adhikari
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Javier Mendoza-Revilla
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Anood Sohail
- Department of Genetics, Cambridge University
- Macarena Fuentes-Guajardo
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Jodie Lampert
- Department of Genetics and Genome Biology, University of Leicester
- Juan Camilo Chacón-Duque
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Malena Hurtado
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
- Valeria Villegas
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
- Vanessa Granja
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
- Victor Acuña-Alonzo
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Claudia Jaramillo
- GENMOL (Genética Molecular), Universidad de Antioquia
- William Arias
- GENMOL (Genética Molecular), Universidad de Antioquia
- Rodrigo Barquera Lozano
- National Institute of Anthropology and History
- Paola Everardo
- National Institute of Anthropology and History
- Jorge Gómez-Valdés
- National Institute of Anthropology and History
- Hugo Villamil-Ramírez
- Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica
- Caio C. Silva de Cerqueira
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Tábita Hunemeier
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Virginia Ramallo
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Lavinia Schuler-Faccini
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Francisco M. Salzano
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Rolando Gonzalez-José
- Instituto Patagonico de Ciencias Sociales y Humanas, Centro Nacional Patagonico, CONICET
- Maria-Cátira Bortolini
- Departamento de Genética, Universidade Federal do Rio Grande do Sul
- Samuel Canizales-Quinteros
- Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica
- Carla Gallo
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
- Giovanni Poletti
- Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia
- Gabriel Bedoya
- GENMOL (Genética Molecular), Universidad de Antioquia
- Francisco Rothhammer
- Instituto de Alta Investigación, Universidad de Tarapaca
- Desmond J. Tobin
- Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford
- Matteo Fumagalli
- Department of Life Sciences, Silwood Park campus, Imperial College London
- David Balding
- Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London
- Andrés Ruiz-Linares
- Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University
- DOI
- https://doi.org/10.1038/s41467-018-08147-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Pigmentation variation in humans is influenced by complex genetic architecture in different populations. Here, the authors perform a genome-wide association analysis involving > 6,000 Latin Americans for pigmentation of skin and eyes, and identify known and novel genetic associations.
