International Journal of Hematology-Oncology and Stem Cell Research (Apr 2009)

Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population

  • Andisheh Ghashghaie,
  • Kamran Alimoghaddam,
  • Mohammad Reza Ostadali,
  • Hamid-o-allah Ghaffari,
  • L Khansari,
  • M Sadraee,
  • E Mirrasekhian,
  • Iranna Mohyedin,
  • F Raoofi,
  • Z Noori,
  • H Yaghmaian,
  • H Eshaghi,
  • Ardeshir Ghavamzadeh

Journal volume & issue
Vol. 3, no. 2
pp. 18 – 20

Abstract

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"nIntroduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matching unrelated donors and recipients for HLA-A, -B and -DRB1 loci is a prediction for an improved outcome. "nMethods and materials: HLA-A and -B of six hundred Iranian cord blood samples were typed by PCR-SSP method and the frequency of loci were estimated. "nResults: The most frequent alleles were A*02(18.16), A*24(16.41), B*35(21.66) and B*51(13.35), respectively. "nDiscussion: Our HLA typing data show similarity between neighbor and related countries and Caucasians. Identifying HLA alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation.

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