Российский кардиологический журнал (Jun 2007)
Clinical and electrocardiographic markers of trimetazide effectiveness in patients with Functional Class II-III effort angina
Abstract
In total, 156 patients with Functional Class (FC) II-III effort angina (EA) received standard therapy (beta-adrenoblockers, ACE inhibitors, disaggregants) plus trimetazide (60 mg/d) for 16 weeks. Control group included 40 patients with FC II-III EA, receiving standard therapy only. Combined therapy was associated with: nitroglycerine dose reduction; physical stress tolerance increase; decrease of qualitative and quantitative signs of pain and painless myocardial ischemia, supraventricular and ventricular extrasystoles, QC dispersion; increase in timely and spectral parameters of heart rate variability.
